Her first international competition was 2005 European Youth Olympic Winter Festival in Monthey, Switzerland, where she won two bronze medals, and 2005 Biathlon Junior World Championships in Kontiolahti, Finland.

Next season she missed internationally, but on 2 March 2007, she debuted in Biathlon World Cup by finishing 44th in sprint in Lahti, Finland.

She was enrolled in the national team for all three last World Cup stages that season but didn't gain any points.

In the first sprint race of that season on 1 December 2012, Olena finished third in Östersund, Sweden, and was second in pursuit in Italian Antholz-Anterselva in January 2013.

She returned in 2015–16 season, which she started with two bronze medals in sprint and individual race in Swedish Östersund.

[6] She graduated from Ternopil Volodymyr Hnatyuk National Pedagogical University, where she studied physical training and sports.

[10] During the awarding ceremony after her victory in the women's relay in Hochfilzen on 8 December 2013, she and other Ukrainian biathletes shouted "For Maidan".

[9] Pidhrushna gained at a news conference after her women's relay victory at the 2014 Winter Olympics a minute's silence in memory of the people who died in Kyiv in the February 2014 Euromaidan riots.

[11] In summer 2021 Pidhrushna married the second time, with former Ukrainian cross-country skier Ivan Bilosiuk, but in January 2025 she declared that they divorced.