[1] Born in Rome to Pietro Aldobrandini and Flaminia Ferracci, she was a sister of Pietro Aldobrandini (1571-1621), who was made a cardinal in 1593 by their uncle Pope Clement VIII.
In 1585 she married Giovanni Francesco Aldobrandini, first prince of Meldola and Sarsina (1545-1601) and had issue: She died in Rome.
In 1612 the Principality of Rossano, the estate of Longobucco and the hamlet of Paludi were bought by her brother Pietro for her son Giorgio Aldobrandini (1591-1637), then under his mother's tutelage.
The sale of the Principality of Rossano cost the University 10,000 ducats, but as this sum was not available the estates of Valle dell'Ambra and San Giovanni in Foresta were ceded to Princess Aldobrandini.
In 1620 she financed the construction of a new church in Corigliano-Rossano dedicated to San Nilo.