[7] Jackson-Cohen attended a French-language school in London, the Lycée Français Charles de Gaulle, and says he has a slight French accent.

[8][9] He attended the Youngblood Theatre Company during weekends, then began washing vases for a florist as a job to support himself financially between auditions.

He also played Marcus in the short film The Rooftopsmiths by Len Rowles with Natasha Freeman as Imogen and Philip Marden as Joel.

[24][25] In March 2014, Jackson-Cohen was cast as James, Duke of York in ITV's four-part period drama miniseries The Great Fire.

[26] It was announced in July 2014 that he would star opposite Sarah Snook in the 2015 ABC convict miniseries The Secret River, an adaptation of Kate Grenville's 2005 novel of the same name.

[29] In the same year, Jackson-Cohen was cast as Lucas in Emerald City, a television series that re-imagined the novel The Wonderful Wizard of Oz by L. Frank Baum.

[43] In June 2022, it was announced that Jackson-Cohen would star opposite Jenna Coleman in the upcoming Amazon Prime Video series Wilderness, a television adaptation of B.E.

The film also stars his Wilderness costar Jenna Coleman, and was shot in December 2022 through January 2023 in various locations across England's Northeast coast.

[48] His experiences informed his performance in The Haunting of Hill House: "I was diagnosed with PTSD a couple of years ago so all of that is in there with Luke - and it felt incredibly cathartic to be able to kind of put it all out there and be there.