He also served as a selectman of Hatfield almost every year from 1731 to 1774 and again in 1780–81; a representative in the Massachusetts General Court 1741, 1761, and 1765–1767; and High Sheriff of Hampshire County from 1741–1743.
Upon his return to Massachusetts from New York he was commissioned a Colonel and succeeded his uncle Israel Williams in command of Britain's provincial forces on the Western frontier.
In 1765 with Samuel Adams, James Otis Jr. and Timothy Ruggles, he was called to represent Massachusetts at the Stamp Act Congress in New York, which resulted in the first official American opposition to British policy.
Partridge signed the Declaration of Rights and Grievances to HM King George III and Parliament in which the American Congress respectfully explained their reasons for their opposition to the Act.
It also led the colonists to focus on the idea of constitutional limitations on parliamentary authority, a concept that contributed to the American Revolution.
Theodore Sedgwick (former Speaker of the House in the George Washington administration) and was elected a Massachusetts Congressman, Senator, Attorney General and U.S.