She is perhaps best known for portraying Lady Adelaide Midwinter in BBC's Lark Rise to Candleford, Grace Darling in BBC3's Personal Affairs, Hermione Roddice in Women in Love, Henrietta Armistead in Garrow's Law, Ava Knox in the HBO/Cinemax co-production Strike Back and Madeleine Mathers in Indian Summers for PBS and Channel 4.

[citation needed] In her final year at Oxford she was invited by Royal Shakespeare Company producer Thelma Holt and the Cameron Mackintosh Fund to take part in a showcase at the Old Vic Studios, where her monologue performance of Juliet Stevenson from Anthony Minghella's film script Truly Madly Deeply led to her being contacted by leading acting agents in the run up to her finals.

Within weeks of graduating Grant was cast in the Paramount film Stardust, in a role which saw her magically transformed from a boy to a goat to a girl by an evil witch Lamia (played by Michelle Pfeiffer).

She then played with fellow Oxford alumni Rosamund Pike and Rory Kinnear in BBC Four's production of Women In Love as Hermione Roddice, which was shot in South Africa.

She also returned to South Africa to shoot the Emmy-nominated HBO / Cinemax co-production Strikeback playing Charles Dance's daughter Ava Knox.