His second studio album, In Case You Didn't Know (2011), debuted at number one in the UK and resulted in two number-one singles: "Heart Skips a Beat" and "Dance with Me Tonight".

[8] Prior to The X Factor, Murs worked at Kitchens Direct as a telemarketer and then as a recruitment consultant at Prime Appointments in Witham, and performed as part of a covers band called the Small Town Blaggers with a friend, Jon Goodey.

[21] Murs performed on The X Factor tour, alongside McElderry, John & Edward, Stacey Solomon, Lucie Jones and several other finalists.

It was later revealed on The Xtra Factor that Murs was predicted by all the judges and presenters (except Minogue who had said Nicole Jackson, and Cole who had said Miss Frank as a second choice) as the favourite to win the series at the Bootcamp stage.

[26] It was later confirmed that Roy Stride, Trevor Horn, Wayne Hector and Matty Benbrook would have involvement on the album which he collaborated with to make the "best possible songs".

[27] More writers and producers were confirmed to be working with Murs in the studio, including: Phil Thornalley, Martin Brammer, Samuel Preston, Mark Taylor,[28] Chris Difford[28] and Professor Green were due to appear on the album; however, the duet fell through before recording was completed.

"[30] The song was described as "a lovely summery reggae-tinged pop tune that bobs along in a thoroughly hummable and not un-Will Young-like fashion" and said that the music video "is just as quintessentially pleasant".

The song was released with the B-side track, entitled "This One's for the Girls" also entered the UK Singles Charts, debuting at number 69, was written for all of his female fans.

"[38] Murs revealed that he will attempt to build himself a more of a "soulful" sound through writing the second album, and also expressed interest in recording with English entertainer Robbie Williams after the two met on The X Factor Live Final.

[39] Murs confirmed in July 2011, that the lead single from the album would be called "Heart Skips a Beat", and it would feature up-and-coming Brithop Rap duo Rizzle Kicks.

[43] On 17 September, Murs announced the first single from his third album, "Troublemaker", a collaboration with Claude Kelly and Steve Robson which features American rapper Flo Rida and was released on 18 November.

Murs will be embarking on a second arena tour of the UK and Ireland in February/March 2013 to support the album, as well as performing his first live European dates in Germany, Switzerland, Sweden and Denmark in April 2013.

Murs was the opening act for English boy band One Direction on the North American leg of their Up All Night Tour, which began on 29 May in Toronto.

While visiting Chicago, IL for a performance of 25 January, Murs spoke with WBBM-FM B96 and confirmed that the final U.S. release date is 16 April 2013 and he will be featured as February 2013's VH1 "You Oughta Know" artist.

In September, was announced that a new French version of "Dear Darlin", with participation of the famous singer Alizée, would be released in the second day of the month, with also the support of a concert in Paris to attack the France market.

Also on the same day Murs announced that he will feature on English entertainer Robbie Williams's upcoming album Swings Both Ways, singing "I Wan'na Be Like You", a song which he had sung on his first attempt to audition for The X Factor.

[52] The first single from the album was "Moves" and featured guest vocals from Snoop Dogg and an appearance from Rowan Atkinson as the waiter in the bar as himself.

On 24 March, In aid of Sport Relief, Murs performed alongside Rizzle Kicks, Vida and JLS at a special charity concert, held at The O2 Arena in London.

Murs' keen interest in football, and support of Manchester United means that he has also frequently appeared on sport based TV shows and radio stations such as Talksport, either during promotion of his music or as a talking head giving his opinion on matches.

[70] In January 2013, as part of celebrations to mark the 150th anniversary of the founding of The FA, Murs was appointed as an FA150 Ambassador, along with other leading figures from the world of football such as Alan Shearer, Gary Lineker and Sir Bobby Charlton.

In January 2013 it was confirmed that Murs would guest star in a season 5 episode of the American drama series 90210 where he would perform "Troublemaker" and "Right Place Right Time".

On 6 October 2013, Murs returned to The X Factor as a guest mentor to help judge Gary Barlow pick his finalist for the finals of the competition.

In February 2011, it was announced that Murs would participate in the BT Charity Trek, with other celebrities, as part of the 2011 Comic Relief Red Nose Day campaign.

The walk intended to raise money for the mental health support charity Samaritans, and named after Caroline Flack, who had died the previous February.

Due to his international release and touring with One Direction over the summer, he was not present for the Xtra Factor audition, boot camp and judges' houses stages of this year's series, but did however record some special segments with selected auditionees that were broadcast in these episodes.

The show featured him performing some of his songs as well as photobomb with Nicole Scherzinger, prank Caroline Flack, appear in a special episode of EastEnders[87] and lip sync with John Bishop.

He invited several guests, including Bradley Walsh, Tom Jones, Emma Willis, Megan McKenna, Rochelle Humes, Chris Hughes and Kem Cetinay.

[92] In 2019, Murs made his acting debut as the voice of Spike the Doberman in a two-part special of the Disney Channel series 101 Dalmatian Street titled "A Summer to Remember".

[95] In 2015, Murs first opened up about ongoing mental health issues, admitting that he turned to alcohol to cope with depression caused by the pressure of a new career during his time on the X Factor tour.

Appearing for a "routine performance" on the Graham Norton Show to promote his new music, Murs was struck with sudden, overwhelming panic, stating his "heart was pounding" and he "couldn't breathe".