Prakash played major characters in films including Dus Lakh, Annadata, Charandas, and Sadhu aur Shaitan.
His pivotal roles in the films Dil Daulat Duniya, Gopi, Apna Desh, Chupke Chupke, Julie, Joroo Ka Ghulam, Aa Gale Lag Jaa, Pyar Kiye Jaa, Padosan, and Buddha Mil Gaya are considered to be among his best, along with Daddu in Namak Halaal and De Silva in Zanjeer.
Once Kumar revealed, "I was only afraid once in my acting career and it was during Gopi when Om Prakashji's performance overshadowed mine".
Baldev Raj Chopra noticed his talent when he was a film journalist and critic; he urged Prakash to carry on with his acting career.
He was sure Om Prakash had the talent to prove himself a versatile actor, later winning acclaim and later had roles in films including Lahore, Char Din, and Raat Ki Rani.
He proved that he could play mature roles with equal ease and depth, as shown in Chacha Zindabad, Khandan, Haryali Aur Raasta, Dil Apna Aur Preet Parai, Pati Patni, Neend Hamari Khwab Tumhare, Mere Hamdam Mere Dost, Annadata, Ek Shriman Ek Shrimati, Doli, Chirag, Amar Prem, Aankh Micholi, Ek Hasina Do Diwane, Anuraag, Zanjeer, Sagina, Aa Gale Lag Jaa, Loafer, Roti, Julie, Khushboo, Lawaaris, Bandish, Sharaabi and Chameli Ki Shaadi.
Om Prakash suffered a massive heart attack at his home and was rushed to Lilavati Hospital in Mumbai.