A member of the National Regeneration Movement (Morena), he has served as Secretary of Security and Civilian Protection in the cabinet of President Claudia Sheinbaum since 2024.

In 2012 he was promoted to state coordinator of the Federal Police in Guerrero and, in 2015, to the Criminal Investigation Agency of the Attorney-General's office (FGR).

[2] On 4 October 2019, he was appointed Chief of Police in the Mexico City government's Secretariat of Citizen Security by Mayor Claudia Sheinbaum.

[3] In that capacity he was wounded in his vehicle during an attempted assassination on 26 June 2020 while travelling down the Paseo de la Reforma; two members of his security detail and a passer-by were killed.

[8] [9] On 5 July 2024, however, president-elect Claudia Sheinbaum announced that García Harfuch was to serve in her cabinet as Secretary of Security and Civilian Protection as of 1 October.