Omer Pasha was a member of the Vrioni landowning family of Berat, Fier and Myzeqe, formerly regions of the Ottoman Vilayet of Yannina, presently in Albania.

He was the founder of the city of Fier in 1864 together with his son, Kahreman Pasha Vrioni.

Vrioni, along with several other Albanian league leaders, was arrested in Preveza and deported to the Dardanelles in 1882 after being invited by Mustafa Assim Pasha, the Ottoman governor general of Yanina to meet with him.

[3] Omar Pasha was the father of Sami Bey Vrioni, Albanian politician and delegate at the Assembly of Vlora of 1912 where the Independence was proclaimed.

[4][5] He was elected member of Albanian High Council of Regency as a representative of the Bektashi community in December 1921, but then resigned as a sign of opposition to Ahmet Zogu and his clan.