[3] Sylvilagus insonus differs from S. brasiliensis (forest rabbit) and S. dicei (Dice's cottontail) in that it has a larger skull, wider zygomatic bone, deeper rostrum, wider carotid foramina and dorsal extensions of the premaxillaries that extend posterior to the nasal instead.

[3][6] In contrast, S. insonus differs from S. cunicularius (Mexican cottontail) with whom it shares its habitat by being smaller in size.

[6] There is no fossil evidence of Sylvilagus insonus, and it is only known from its type locality in the province of Guerrero, Mexico.

[6] S. insonus is endemic to Mexico[5][7] and is found only in the Sierra Madre del Sur of the State of Guerrero.

[3][4][6] It is only known from its type locality, Omiltemi Ecological State Park, located in a wooded summit of a semi-isolated mountain range.

[3] Surrounding the wooded area is the village of Omiltemi at 2,332 m (7,651 ft) above sea level (in Municipio Chilpancingo).

[4][5] The Omilteme cottontail lives at the summit of a mountain range which has steep slopes and ravines covered with dense cloud forests.

[3] In the dense cloud forests, the rabbit lives amongst the undergrowth where it makes runways and burrows under objects such as rocks.

[3] According to the IUCN Red List of Threatened Species, the Omilteme cottontail is data deficient.

[8] During an expedition between 2020 and 2022, some scientists rediscovered this species in Mexico in the Sierra Madre del Sur aera, helped by local population and hunters.

This expedition was part of a larger effort to re-discover species, that have not had a scientifically documented sighting in at least 10 years, but are not extinct; leaded by Re:Wild organization.