[4] Omni Air International is a FAA Part 121 certificated airline with IATA Operational Safety Audit (IOSA) registration.

Omni Air International cooperates with Immigration and Customs Enforcement (ICE) in controversial (sometimes termed "high-risk") deportations.

They also flew between Minneapolis/St.Paul (MSP) and Cancun (CUN), Cozumel (CZM), Mazatlan (MZT) and Ixtapa/Zihuatanejo (ZIH), Mexico and to Montego Bay, Jamaica (MBJ) year round and between Boston (BOS) and Aruba (AUA), Netherlands Antilles seasonally.

Omni also occasionally operates sub-service/wet-lease flights for foreign airlines from Canada, Germany, Ireland, Poland, Cyprus, Saudi Arabia, and Bolivia.

In 2011, Omni retired the McDonnell Douglas DC-10s from the fleet and received its IATA Operational Safety Audit (IOSA) registration.

The airline was contracted by the Civil Aviation Authority under the instruction of the British government to operate rescue flights returning stranded Thomas Cook passengers to the UK.

"[10] In August 2021, U.S. President Joe Biden activated the Civil Reserve Air Fleet, utilizing 18 aircraft from six commercial airlines to ferry evacuees of Afghanistan from interim waystations throughout the Middle East and Europe.