[6] In its first decade of operation, Omnivore released approximately 400 albums, including archival music by a broad assortment of notable acts, including Arthur Alexander, America, the Bangles, the Beach Boys, Big Star, the Blind Boys of Alabama, Tim Buckley, Sandy Bull, Camper Van Beethoven, Alex Chilton, Gene Clark, Dennis Coffey, Continental Drifters, Culture, Bobby Darin, Dion, Dr. John, The Dream Syndicate, David "Honeyboy" Edwards, Fastball, Maynard Ferguson, Neil Finn, Game Theory, Allen Ginsberg, Andrew Gold, Vince Guaraldi, Arlo Guthrie, Woody Guthrie, Merle Haggard, John Wesley Harding, Judy Henske, Peter Holsapple and Chris Stamey, Wanda Jackson, Jan and Dean, Bert Jansch, Jellyfish, George Jones, Paul Kelly, The Knack, Lone Justice, Malo, Iain Matthews, Les McCann, Kate and Anna McGarrigle, The Motels, Bob Mould, Harry Nilsson, NRBQ, Old 97s, Buck Owens, Van Dyke Parks, Jaco Pastorius, Art Pepper, The Posies, Alan Price, Raspberries, Bobby Rush, Leon Russell, Soul Asylum, The Staple Singers, John Stewart, 10,000 Maniacs, Richard Thompson, Townes Van Zandt, Hank Williams and Brian Wilson, as well as vintage comedy recordings by Ernie Kovacs and Edie Adams.

[17][18] Omnivore's initial releases were a pair of limited-edition vinyl issues for Record Store Day on April 16, 2011: the Big Star album Third [Test Pressing Edition],[19] and the 7″ single "Close Up the Honky Tonks" by Buck Owens.

[7][8] The label releases recordings in a wide variety of formats, including but not limited to CD, digital, vinyl, flexi discs, cylinders and more.

[5] Billboard noted the "great historical significance" of Omnivore's limited-edition release in April 2012 of a rare recording of Buck Owens performing at the White House for President Lyndon Johnson in 1968, newly pressed by Omnivore on flexi discs in red, white, or blue, each copy packaged with an original uncirculated coloring book that had been commissioned by Owens in 1970 and preserved unreleased for over 40 years.

[25][26][27][28][29][30][31] Omnivore's first Grammy-winning release was Hank Williams' The Garden Spot Programs, 1950, which won a 2014 Grammy Award for Best Historical Album.