The Omono River (雄物川, Omono-gawa) is located in Akita Prefecture, Japan.

The river flows from Mount Daisen on the border of Akita Prefecture with Miyagi and Yamagata Prefectures in the city of Yuzawa and drains into the Sea of Japan at the city of Akita.

The river's drainage basin is essentially the entire southern half of Akita Prefecture.

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