It was the first single from Freak of Nature to be released in the United States, peaking at number one on the Billboard Dance Club Play chart.

"One Day in Your Life" was written by Anastacia and co-written with and produced by Sam Watters and Louis Biancaniello.

[3] Jose F. Promis from AllMusic called it "dramatic" and said that "it follows the same formula as her previous hit, 'I'm Outta Love,' but better, with more soaring, epic vocals, and sounds like a rock version of a forgotten disco classic.

Anastacia performed "One Day in Your Life" at several live events such as the Edison Awards on February 27, 2002 (where she won the award for Best International Female), VH1's Divas Las Vegas on May 23, 2002, the Royal Variety Performance on December 2, 2002, and the Life Ball on May 20, 2006, as well as on television shows like Live with Regis and Kelly in the United States, Top of the Pops in the United Kingdom, Wetten, dass..?

In the beginning, while the sun is rising up, Anastacia is shown eating a bowl of cereal for breakfast, while singing the first verse of the song.