One Music PH's website went live in November 2015, but the brand was officially launched on noontime musical variety show ASAP on June 3, 2016 [1] with performances from Yeng Constantino, Ylona Garcia, Erik Santos, and Jed Madela among others.

Initially a discovery platform for new music artists, One Music PH has then produced musical shows like One Music POPSSSS [2] (hosted by Alexa Ilacad, Iñigo Pascual, Maris Racal, John Roa, Tony Labrusca, AC Bonifacio, and Ryle Santiago), One Music LIVE, and Wander Jam[3] (hosted by Migz Haleco, Sue Ramirez, and Ryle).

[4] The brand is also responsible for the creation of "One Paradise," a musical event that advocates for environment protection through music [5] with the first two concerts being held in La Union[6] One Music PH temporary stopped its operations on August 31, 2020, as part of the retrenchment by ABS-CBN Corporation, due to denial of ABS-CBN's legislative franchise by the House of Representatives on July 10, 2020.

[7] In August 2021, One Music PH resumed its operations following the announcement of ABS-CBN's expansion of digital content thru YouTube.

It was also announced that the brand is set to launch "The Music Room", a weekly digital concert series featuring breakout Filipino artists exclusively on One Music PH's YouTube channel.