By 1528, it was owned by the Opacki family of the heraldic clan of Prus, and its estate had an area of 6 lans, which equals to around 100 ha.

[3][4] In the 18th century, the village became property of Arnold Anastazy Byszewski, who was a general and aide-de-camp in the Crown Army of the Polish–Lithuanian Commonwealth.

[3][4] In the late 19th century, to the southeast from Opacz Wielka were formed three small artificial lakes, known as Załuski Clay Pits.

The building restrictions imposed on the neighbouring settlements, including Opacz Wielka, had stopped their developments.

[7] On 6 March 1944, while Opacz Wielka was under German occupation during the Second World War, six officers of the Home Army were captured there by the Volksdeutsche Nazi sympathisers, and executed by the Field Police Corps.

In May 1944, a division of the Directorate of Diversion of the Home Army, had executed four people responsible for the capture of Polish resistance soldiers, and two more were killed in the following weeks.

[2] In the southeastern portion of the neighbourhood, near Emaliowa Street, are located Załuski Clay Pits, two small artificial lakes.

[11] At the southern and eastern boundary of Opacz Wielka are located two intersecting expressways that form part of the ring road around Warsaw.