The foundation seeks to support local partners working to promote and protect human rights, the rule of law, justice, accountability, and transparency in Armenia.

The foundation responded with supplying humanitarian aid, equipment, and technology to Armenia's schools, universities, libraries, and healthcare facilities that were struggling to adapt to the new economic pressures.

[4] On 22 October 2013, the foundation organized a presentation of the "European Integration Index for Eastern Partnership Countries" report that OSF Armenia had conducted.

[1] The foundation has also supported community-based mental health institutions and improving conditions within prisons, psychiatric wards, and old-age homes across the country.

[11] To date, the foundation has invested over $1.5 million to support the work of various women's rights organizations, including the provision of emergency services to victims of domestic violence.

[17] Minasian stated, "A large-scale counterpropaganda and an unprecedentedly aggressive information campaign, accompanied by hate speech and often overt calls for violence, is waged against the foundation and our partners for quite some time" and "the effort is aimed at preventing OSF from supporting various reforms announced by the Armenian government.

They also seek to target public trust in our country's democratic institutions, the legitimately elected National Assembly and the government formed by it.

In June 2022, Armenian lawyers Tigran Atanesyan and Margarita Gyulumyan asked a local court to shut down OSF Armenia citing the office's operations as a "threat to national security and public order".