Opočno (German: Opotschna) is a municipality and village in Louny District in the Ústí nad Labem Region of the Czech Republic.

Opočno lies approximately 7 kilometres (4 mi) south-west of Louny, 45 km (28 mi) south-west of Ústí nad Labem, and 55 km (34 mi) north-west of Prague.

The first written mention of Opočno is from 1358.

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