Samuel Opoku Nti (born 23 January 1961) is a Ghanaian former professional footballer who played as a forward.
He is generally considered to have been Ghana's top footballer in the early to mid-1980s; before the international advent of Abedi Pele.
Opoku Nti featured in Ghana's victorious 1982 African cup winning side as well as the unsuccessful 1984 squad; which was eliminated in the 1st round of the competition.
In the 1992 African Cup, he was controversially left on the substitutes bench for the majority of the tournament in favour of Mohammed Gargo, Stanley Aboraa, and Nii Lamptey - all of whom were considerably less experienced than Nti.
This was the year that Opoku Nti's match-winning goal made Asante Kotoko win the Africa Clubs Championship by beating Egypt's Al-Ahly in the final at Kumasi.