Opoul-Périllos (French pronunciation: [ɔpul perijɔs] ⓘ; Occitan: Òpol i Perellós, IPA: [ˈɔpul i pəɾəˈʎos]) is a commune in the Pyrénées-Orientales department in southern France.

In its present form it dates from January 1, 1972, when both villages where integrated into one single commune (Perellós, a tiny hamlet located some 10 km up into the mountain, had been virtually deserted since the end of World War II, the 1968 census returning just 4 inhabitants).

It would be logical to assume *Opedol as a diminutive form of Oped, which could have designated a small castle in the village as opposed to the fortress which dominates it (it is worth mentioning that the medieval fortress overlooking the village has been known as "castell de Salvaterra" from the 13th century onwards (salvaterra being Catalan for "safe land", "asylum place").

It was during the 19th century that population growth reached its peak, bolstered by a lower mortality rate and the development of viticulture: 701 inhabitants in 1836, 1157 in 1886.

As for Périllos, a village virtually cut off from the world, its decline was inevitable: after reaching a peak of 85 in 1861, population fell to 8 people in 1946, the last birth being registered in 1916.