The town is located 12 kilometres (7.5 mi) upstream from the mouth of the river Neretva, in southern Dalmatia.

This settlement is known as a major center of tangerine production in Croatia.

Ruins of the fortress that remain are called Recycle and are part of the old town wall.

The center of the old part of Opuzen is a classic Roman Forum.

The marathon is held on the river Neretva and about 35 boats participate each year.