[4]: 636 By the 1890s, Nincehelser's practice had made him a wealthy man;[5] Mechanicsburg's growth was attracting many professionals, and he was one of at least three physicians active in the community.

[6]: 6  Accordingly, after marrying a woman from New York City, he arranged for the construction of a large Queen Anne-style house on Main Street just north of downtown Mechanicsburg.

The magnificent new residence was built primarily to impress his new bride, but the couple did not live long in the house: Mrs. Nincehelser deserted her husband after just a few years of marriage.

[5] In later years, the original meeting hall of Mechanicsburg's Odd Fellows lodge burned,[6]: 7  and Nincehelser sold his home to them in 1931; he had lived alone in the house since his wife left him.

[7] Uniformity is absent from the design; the primarily hipped roof of the two-and-a-half-story residence comprises multiple components, the overall floor plan is asymmetrical, and the windows are of diverse shapes and sizes.