Orangeburg-Wilkinson High School is located in Orangeburg, South Carolina.

It is a part of the Orangeburg County School District.

It is home to the Mighty Bruins/Bruinettes and also an International Baccalaureate World School.

[2] Delano Middleton, a student at Wilkinson High School, was one of those killed in the Orangeburg Massacre.

[3] In 2016, the school was featured in the six-part BBC documentary series Segregated America: A School in the South.