OSL owns and operates the DiMenna Center for Classical Music, and is administratively located at 450 West 37th Street in Manhattan's Hell's Kitchen neighborhood.
In the 1984/85 season, Carnegie Hall invited the orchestra to perform as part of a Handel Opera Festival, conducted by Charles Mackerras, Raymond Leppard, and John Nelson, and which featured performers including Marilyn Horne, June Anderson, Tatiana Troyanos and Kathleen Battle.
Sir Charles Mackerras was the orchestra's second music director, from 1998 to 2001, but with limited administrative work and only for the designated 3-year period, per his request.
In December 2011, the orchestra announced the appointment of its current principal conductor, Pablo Heras-Casado, with immediate effect, and with an initial contract through 2015 and an extension through September 2017.
Orchestra of St. Luke's has premiered more than 100 orchestral and chamber works by such composers as John Adams, Joan Tower, Gabriela Lena Frank, Valerie Coleman, Anthony Davis, Nicholas Maw, André Previn, George Tsontakis, Bryce Dessner, Ellen Taaffe Zwilich and Alma Deutscher.
The orchestra has appeared on more than 100 recordings, four of which have won Grammy Awards: John Adams's Nixon in China, Samuel Barber's Knoxville: Summer of 1915, Listen to the Storyteller with Wynton Marsalis, and Bel Canto with Renée Fleming.