Her films include Il vizio di famiglia directed by Mariano Laurenti, Per amare Ofelia by Flavio Mogherini, Concerto per pistola solista by Michele Lupo, Colpo di Stato by Luciano Salce (1969) and Paolo il caldo by Marco Vicario (1973).

She appeared briefly in Il nero by Giovanni Vento (1965) and Una macchia rosa by Enzo Muzii (1970).

Her theater work includes comedies such as Morto un Papa se ne fa un altro, Strega Roma and Chicchignola written by Ettore Petrolini, all of which were directed by Ghigo De Chiara and Fiorenzo Fiorentini.

De Santis appeared in Sottoveste by Castellacci e Ventimiglia and Love and Life by Mike Immordino.

For the RAI radio, De Santis appeared in many roles, mainly in the serials Barocco a Roma and Racconto italiano which were broadcast in the late 1970s.