(Another such split occurred in California, but with the decommissioning of U.S. 99, that state elected to rename its U.S. 99W as Interstate 5, rather than preserve the directional suffix.)

North of Tangent, the route enters the city of Albany and serves as a main thoroughfare through town (for about a mile, OR 99E shares an alignment with US 20).

North of NE Broadway, OR 99E continues as MLK Jr. Boulevard and passes through several Northeast Portland Neighborhoods until its terminus at an interchange with I-5 and OR 120 in Delta Park, just south of the Columbia River crossing.

[1] The parallel highways ran through the Willamette Valley and the suffixed designations were proposed by cities on the west side.

[2] In the 1950s and 1960s,[citation needed] I-5 (also signed as US 99 Bypass) was built parallel to US 99E and absorbed the Albany–Salem section of the highway to form a concurrency.