The area of the district is 1,821.28 square kilometers (703.20 sq mi).

[7] The landscape of the district is mostly a hilly plain with average altitude of about 130 meters (430 ft) above sea level.

Climate, flora, and fauna are common for Meshchera Lowlands.

Within the framework of administrative divisions, Orekhovo-Zuyevsky District is one of the thirty-six in the oblast.

[1] The city of Orekhovo-Zuyevo serves as its administrative center, despite being incorporated separately as a city under oblast jurisdiction—an administrative unit with the status equal to that of the districts.