Organic Process Research & Development is a peer-reviewed scientific journal published since 1997 by the American Chemical Society.

[1] Its publication frequency switched from bimonthly to monthly in 2012.

It is indexed in Chemical Abstracts Service, Scopus, EBSCOhost, British Library, and Web of Science.

The current editor-in-chief is Kai Rossen.

[2] According to the Journal Citation Reports, the journal has a 2021 impact factor of 3.858.