A unique feature of the review process is that all of the data and experiments reported in an article must be successfully repeated in the laboratory of a member of the editorial board as a check for reproducibility prior to publication.

[3] An annual print version is published by John Wiley & Sons on behalf of Organic Syntheses, Inc.

Prior to World War I, work on synthetic organic chemistry in the United States had been quite limited, and most of the reagents used in laboratories had to be imported from Europe.

The procedures were finally collected and published for the first time in a four-pamphlet set called Organic Chemical Reagents, which quickly sold out.

In that year, all past volumes were made available on an open access website and new articles are now published online as soon as they are accepted.