She has released about 112 works between LP, EPs and greatest hits albums, and is considered one of the most popular interpreters of Italian pop music.

[citation needed] Vanoni scored two major hits in 1963 with "Senza fine" and "Che cosa c'è", both written for her by Gino Paoli.

In 1972 she sang "Quei giorni insieme a te", the theme from Lucio Fulci's critically acclaimed mystery thriller film Don't Torture a Duckling.

[3] In addition to her music career, Ornella Vanoni was active in other creative fields, starring in stage and TV shows, movies.

In January 1977 she posed nude for the Italian edition of Playboy magazine and requested a statuette by her long time friend the artist Arnaldo Pomodoro as payment.