As the name suggests, Orphan School Creek was named after an orphan school in the area.
[1] It starts in Allambie Road Reserve, Bossley Park, on the border with Edensor Park, and flows in a generally eastern direction before emptying into Prospect Creek.
The creek is a mostly natural waterway that is surrounded by Coastal Swamp Oak Forest, with only the middle reach flowing through a concrete channel and piped system (around Wakeley).
[2] It is approximately 10 kilometres (6.2 mi) in length, and has two tributaries, Clear Paddock Creek and Green Valley Creek.
The following roads and railways form crossings over Orphan School Creek.