Archaeological excavations and researches to be carried out in settlements with more than one cultural level, such as Kalehöyük, Koçhasan Mound and Muratlı Höyük around Ortaköy, will yield new documents for the Hittite period.

Among the "burial" methods seen in Phrygian culture, "Rock Graves" made by carving are not encountered due to the geological structure of the regions.

Upon the death of Alexander the Great in 323, the Kingdom of Cappadocia, founded by Arırarat, a Persian descendant, dominated the region.

Small and large settlements from these periods, goddesses made of marble, coins in agricultural activities and illegal excavations are frequently encountered in the lands of Ishaklı, Karapınar, Sarıkaraman, Namlıkışla villages.

Christian people have established underground cities in order to get rid of this brutality and to worship more freely.

There are coins, terracotta pots, drinking water networks, mortared dwelling remains, graves and various mining enterprises from this period in Ortaköy and its surroundings.

In order to resist and protect these invasions, the strategic points and derbents in the south were carefully preserved by the Byzantines, passages were kept close to Ereğli (Heraklia), Niğde, Aksaray (Arkhelais) and Ortaköy, and new castles were built.

Melik Ahmet Danişmend Gazi, one of the commanders of the Great Seljuk state, who entered Anatolia with the Battle of Manzikert in 1071, conquered Aksaray and its surroundings and turned these places into a Turkish homeland.

(1243) As a result of the defeat of Kösedağ and the settlement of the Mongols in Anatolia, the authority of the Anatolian Seljuk rulers was weakened.

Due to the state authority vacuum that occurred as a result of this, Ortaköy and its surroundings also changed hands between Eretna, Kadı Burhaneddin and Karamanoğulları.