Enderlein started her working career at the SC Traktor Oberwiesenthal, and was first introduced to luge in her home village of Raschau in the Ore Mountains.

[9] Enderlein began her sporting career in as a handball player for the eight division BSG Rotation Raschau, sometimes playing as goalkeeper in 1964.

[14] She debuted at the FIL World Luge Championships 1963 in Imst, but achieved only 24th place after a fall, while her teammate Ilse Geisler won.

[15] A few days later, Enderlein finished second behind Geisler, at the international event for the "Ehrenpreis der Stadt Innsbruck" on the newly created Bob-Rodel Igls run in Innsbruck-Igls.

[17] Enderlein debuted and won at the 1964 Winter Olympics in Innsbruck with the best time in all four heats, each on 30, 31 January and 4 February, with a 0.75 second advantage over Ilse Geisler and Austrian Helene Thurner.

[23] In June 1964, together with Thomas Köhler, who was also victorious at the Olympics, Enderlein was awarded the Patriotic Order of Merit in Silver in celebration of the Week of Youth and Sports.

[6] The GDR politicised its athletic achievements in its fight for recognition as an independent country and for the right to field its own teams at future Olympic Games.

[26] Because of her consistent achievements, Enderlein was ranked third in the vote for East German Sportswoman of the Year, behind Hannelore Suppe and Gabriele Seyfert.

[19][29] Because of the Hallstein Doctrine, the East German lugers were not permitted to compete at the FIL European Luge Championships 1967 at Königssee.

[31] Enderlein, who at that time was named the "world's most perfect female luger",[32] won at the January 1968 Alpine Cup Race in Imst as the fastest in the three heats.

[7] East German Horst Hörnlein was disqualified for the same reason at the 1967 World Championships, although it was caused by the heating in the tent where he prepared his sleigh for the start, and the runners had not fully cooled.

[38] After the Olympic Games in Grenoble, Enderlein took first place in three out of five runs at the GDR Championships in Friedrichroda on 24 and 25 February 1968, ahead of Angela Knösel and Anna-Maria Müller.