Oruchuban Ebichu is very adult in nature, and its comedy, explicit violence, innuendos, and sexual intercourse scenes could only be shown on DirecTV Japan.

[5] Each adventure chronicles the housekeeper female hamster Ebichu, devoted to her oft-indifferent owner, who she calls Goshujin-sama ("Master") and is only identified as OL ("Office Lady"), a single 28-year-old (she is 25 years old in the anime series) who doles out cynical commentary and the occasional beating on the rodent.

Kotono Mitsuishi, the voice actress for the character of Misato Katsuragi, would read the Ebichu manga in between takes and laugh at the humor.

Ebichu is sometimes joked by fans to be the complete polar opposite of Hamtaro, a popular children's anime featuring a hamster in more wholesome adventures.

The ending theme, shared with the other shows in the Modern Love's Silliness block, is "Kumokumo Gake ni Konma Takeyafu" (くもくもがけにこんまたけやふ) by Minami Karasuyama 6th Street Production.