Orzinuovi (Italian pronunciation: [ordziˈnwɔːvi]; Brescian: I Urs Nöf) is a town and comune in the province of Brescia, in Lombardy, Italy.

It was founded in 1193 by statute of the comune of Brescia, as a boundary fortress with the name of "Orci Novi".

Its history thenceforth closely follows that of Brescia, sharing the Venetian dominion from 1466 until Venice's demise in 1797.

This continued until the Second Italian Independence War.

In the 2010s, Orzinuovi was involved in an illicit traffic of solid toxic waste treatment which concerns the bordering municipalities.