[2] Their work often features yellow-skinned characters—taken from the yellow tinge both of the twins have in their dreams—but is otherwise diverse and ranges from tags to complicated murals.

Subjects range from family portraits to commentary on São Paulo's social and political circumstances, as well as Brazilian folklore.

[3]: 159 Their first significant artistic influence outside their immediate environment, and their limited access to American hip hop (Style Wars, Subway Art, Beat Street), stemmed from a chance encounter with Barry McGee (also known as Twist), who was in Brazil for several months on a study abroad program through the San Francisco Art Institute in 1993.

[4] Titled "The Foreigner," the piece was originally scheduled to be shown for thirty days, but public approval allowed it to remain until the demolition of the building in 2012.

[4] For the 2014 FIFA World Cup in Brazil, the duo were commissioned to decorate the national soccer team's official Boeing 737 aeroplane.

It was the inspiration for the large opening act where the head character came to life in association with the French group La Plasticiens Volant.

[11] The festival features artists from Brazil and Belarus collaborating on mural productions in the Belarusian capital city of Minsk.

Other cities in Europe which feature the work of OSGEMEOS include Vilnius, Lithuania;[12] Milan, Italy;[13][14] Malaga, Spain[15] and Berlin, Germany.

[16] Their first solo exhibition the United States was held at the Luggage Store Gallery in San Francisco, California in spring 2003 and was titled "Pavil" (or "Wick"); they also created a 25-foot by 15-foot mural on the side of the Luggage Store Gallery building on Market Street.

[19] The piece, created in collaboration with the ICA and Rose F. Kennedy Greenway Conservancy, depicted a young, yellow figure with its face wrapped in a red shirt.

[23] In 2013, they collaborated with luxury brand Louis Vuitton to design a scarf, alongside artist Retna and Lady Aiko.