Ōsakikamijima (大崎上島町, Ōsakikamijima-chō) is a town located in Toyota District, Hiroshima Prefecture, Japan.

As of 31 March 2024, the town of Ōsakikamijima had an estimated population of 6,744 and a density of 160 persons per km2.

A bridge to the nearby Ōsakishimojima, which is linked with the mainland via the Akinada Tobishima Kaido, has been planned since 1972 but construction is yet to start.

There are ferry services to Ōsakishimojima, Ōmishima Island, Takehara (Honshu) and Imabari (Shikoku).

Hiroshima Global Academy is the newest school in Osakikamijima, it was opened in 2019.