Osina Duża [ɔˈɕina ˈduʐa] is a village in the administrative district of Gmina Kiełczygłów, within Pajęczno County, Łódź Voivodeship, in central Poland.

It lies approximately 2 kilometres (1 mi) north of Kiełczygłów, 12 km (7 mi) north of Pajęczno, and 68 km (42 mi) south-west of the regional capital Łódź.

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