The train services are operated by Deutsche Bahn, Hamburg-Köln-Express, NordWestBahn, Eurobahn and WestfalenBahn.

The station features two levels, with lines at right angles to each other.

Close to the railway stations are several stores including a cinema, a döner shop, an escort service, and a disco.

The following services currently call at Osnabrück Hauptbahnhof:[5] Many bus services depart from the bus station outside the station.

A coach shuttle service to Münster Osnabrück Airport operates from the station, taking approximately 40 minutes to get from the railway station to the airport.