It flows through the Moravian-Silesian Region in the Czech Republic and through the Opole Voivodeship in Poland.

[1] The name is of pre-Slavic origin and there is a theory that name may be derived from the root as-, meaning 'dry'.

[2] The Osobłoga originates in the territory of Petrovice in the Zlatohorská Highlands at an elevation of 743 m (2,438 ft) and flows to Krapkowice, where it merges with the Oder River at an elevation of 158 m (518 ft).

[5] The longest tributaries of the Osobłoga are:[3] The river flows through the municipal territories of Petrovice, Janov, Jindřichov, Vysoká, Dívčí Hrad, Bohušov and Osoblaha in the Czech Republic and through the territories of the gminas of Głogówek, Głubczyce, Strzeleczki and Krapkowice in Poland.

[6] Among the protected animal species living in the Osobłoga are the common minnow, Alpine bullhead and brook lamprey.