[3] The construction lasted three and a half years, between November 15, 1788, when the pontiff laid the first stone, and March 1, 1792, when the hospital was inaugurated.
[2] The project was designed by the neoclassical architect Francesco Belli, pupil of Giovanni Antinori,[4][5] who partly reused an existing building.
[3] In the worst period of the famine the two hospitals housed together 17,000 sick people, about 10% of the Roman population of the time.
[2] Several prominent medical scholars became directors of this hospital, beginning with Professor Giuseppe Costantini, Papal Archiater under Pius IX.
[1] The facade of the building, 137 meters long,[5] was marked by giant order lesenes, a belt course and rectangular windows running along its entire length.
[2] Several architectural elements of the San Carlo aisle, such as portals, inscriptions, and column shafts in peperino with pulvins in travertine, plastered to imitate marble, are preserved in the municipal storerooms.