Ossuccio (Lombard: Ossusc) is a comune (municipality) in the Province of Como in the Italian region Lombardy.

As of 31 December 2004, it had a population of 975 and an area of 8.0 square kilometres (3.1 sq mi).

[2] It is known for the Sacro Monte, a site of pilgrimage and worship close to it, for the late 16th century Villa del Balbiano [1], the mid-20th century Villa Leoni [2], and for the island of Comacina which falls within its territory.

Ossuccio borders the following municipalities: Colonno, Lenno, Lezzeno, Ponna, Porlezza, Sala Comacina.

The Comune di Ossuccio will be united to Mezzegra, Lenno and Tremezzo to form a single municipality named Tremezzina: the new administration will be formalized after election of the Major on 25 May 2014.