They are named after the Ostioneros de Guaymas, a defunct baseball team which was a charter member of the Mexican Pacific League.

The Ostioneros de Guaymas played their debut season in 2009 and finished third in the North Zone with a 20–20 record.

Ostioneros forward Jerome Habel led the team with 19 points and 11 rebounds in their 94–61 blowout victory in game 7.

[6] The Ostioneros defeated the Fuerza Guinda de Nogales in five games in the quarterfinals before beating the Tijuana Zonkeys in a seven-game semi-final series to qualify for their its first CIBACOPA finals.

The Ostioneros finished the year with a league-best 28–10 record and second in the general table, behind only the Náuticos de Mazatlán.

[17] They beat the Tijuana Zonkeys in the quarterfinals but were once again eliminated in the semi-finals, losing in five games to the Rayos de Hermosillo.

[20] The team failed to reach the playoffs, losing the eight seed to the Halcones de Ciudad Obregón on a tiebreaker.

[24] In February 2022, Guaymas hired longtime NBA assistant John Welch as their new head coach ahead of their return to play.

[26] However, they were eliminated in the first round of the playoffs by the Venados de Mazatlán, who came back from a 3–0 series deficit to beat Guaymas 93–85 in game 7.

They opened the season with a 141–140 victory over the Rayos de Hermosillo in six overtimes, setting a new record for the longest game in league history.