Otego is a town located in the southwest portion of Otsego County, New York, United States.

Tension between ethnic Germans and New Englanders slowed early development.

The Otsdawa Creek Site was listed on the National Register of Historic Places in 1980.

[3] According to the United States Census Bureau, the town has a total area of 44.9 square miles (116.2 km2), all land.

Otego Creek enters the Susquehanna River east of the eastern town line.

Interstate 88 and New York State Route 7 follow the course of the Susquehanna River.