Otis Griffin (born August 22, 1977) is an American professional boxer and ranked light heavyweight contender.
He captured the NABO light heavyweight championship with a technical knockout over unbeaten prospect Mike Nevitt.
In July 2007, Griffin lost by a technical knockout to light heavyweight champion Danny Green of the World Boxing Association at Challenge Stadium in Perth, Australia.
In May 2010 Griffin won a USBA title belt after he knocked out former WBA super middleweight world champion Byron Mitchell.
Griffin was a contestant on the reality TV show The Next Great Champ on Fox.