Otisville is a village in Forest Township, Genesee County in the U.S. state of Michigan.

The first land entry for the Forest (after the heavy growth of trees) community was made in March 1836 by James Seymour.

The township was organized in 1837, with the second settler, Nathaniel Smith, elected supervisor.

[4] In 1851, a sawmill was built by John Hayes, who sold the mill to Francis Otis the next year.

[4] On February 14, 1855, the post office opened with postmaster John Crawford.

In 1874, a station opened by the Pere Marquette Railway in the village.

30.4% of all households were made up of individuals, and 10.8% had someone living alone who was 65 years of age or older.

23.9% of all households were made up of individuals, and 9.0% had someone living alone who was 65 years of age or older.