Otisville is a village in Orange County, New York, United States.

The community was named after Isaac Otis, an early settler and local merchant.

[4] A former sanitarium located near the village is now a New York state prison.

[5] According to the United States Census Bureau, the village has a total area of 0.7 square miles (1.8 km2), all land.

There were 373 housing units at an average density of 537.8 per square mile (207.6/km2).

The racial makeup of the village was 89.48% White, 5.97% African American, 0.30% Native American, 0.61% Asian, 0.10% Pacific Islander, 0.51% from other races, and 3.03% from two or more races.