Ottendorf-Okrilla is a municipality in the Bautzen district, Saxony, Germany.

The municipality is subdivided into the Ortsteile Grünberg, Hermsdorf, Medingen and Ottendorf-Okrilla.

The municipality Ottendorf-Okrilla was formed in 1921 by the merger of the former municipalities Ottendorf, Moritzdorf, Großokrilla, Kleinokrilla and Cunnersdorf.

In 1994 Grünberg joined the municipality, and in 1999 Hermsdorf and Medingen.

It is also the location of the letter processing center of the Deutsche Post for the Dresden area.