Otumfuo Osei Tutu was named after his paternal grandfather, Ohenenana Kwaku Duah (Nana Agari), Brahyiahene, of Kentinkyere in the Atwima district.

[10] When he was about five years old, Otumfuo moved into the royal household of his uncle, Oheneba Mensah Bonsu, the Hiahene, enstooled in 1952, as early preparation for his future role.

His father had other offspring from other marriages, including Yaw Boateng, Kwaku Duah, Kwabena Agyei-Bohyen, Afua Sarpong and Ama Agyemang (Kumasi, Ashanti), Fredua Agyeman Prempeh, Nana Kwasi Agyemang Prempeh and Nana Kwasi Boachie Gyambibi (Kumasi, Ashanti).

He then founded his own mortgage finance firm, Primoda Financial Services Limited, located on Kilburn High Road, North-West London.

[12][13][14][15][16] He received international media attention after some of the Ashanti crown jewels were allegedly stolen from an Oslo hotel in October 2012 when he was attending a conference in the Norwegian capital.

[22] Asantehene Otumfuo Osei Tutu II resides at the Manhyia Palace in Kumasi, the capital city of Ashanti region [23] President John Agyekum Kufuor instituted the Committee of Eminent Chiefs, headed by Osei Tutu II, to intervene in the 2002 Dagbon chieftaincy crisis.

The committee's mandate included facilitating negotiations and mediating talks between the Andani and Abudu royal families, and drawing a roadmap for the restoration of peace in the Kingdom of Dagbon.

[25] In December 2019, Bukali II paid a courtesy call on Otumfuo Osei Tutu at the Manhyia Palace, to express his gratitude for the role the Asante king played in the peace process.

Dignitaries like Nana Addo Dankwa Akufo-Addo, Michael Ashwin Satyandre Adhin the vice president of Suriname and Torgbui Sri, the Awomefia of the Anlo state were in attendance.

[37] In June, the Chief of Kwaso, Nana Nketia Boampong II was destooled after being found guilty of defrauding and multiple sale of lands.

[38] In August 2023, the Chief of Adumoa in the Afigya Kwabre District, Nana Osei Tiri Ababio, was destooled for multiple land-related sales and violating customary procedures by not adhering to Otumfuo's directives.

[41] In December, Nana Baffour Adugyemfuo Kumani, the Chief of Kwapra in Suame Municipality was destooled for engaging in the double sale of lands and violating the Great Oath.

The tree planting initiative is a collaboration between the Oheneba Poku Foundation and Manhyia Palace as well as the Forestry Commission, the Environmental Protection Agency (EPA), the Water Resources Commission, the Ghana Tourism Authority, UNESCO, the District Assemblies of Bosome-Freho and Bosumtwe, and the Lake Bosomtwe Community Resources Management Areas (CREMA), which is an NGO are the other stakeholders.

[48] The National Association of Private Lotto Operators and Agents in Ghana expressed their preparedness to embrace the game so its objective would be achieved.

[49] On 19 July 2024, Osei Tutu delivered a keynote address at the British Museum in London on the theme "Asante Culture and Heritage" to mark his silver jubilee as Asantehene.

This was to show appreciation to teachers who were working in poverty stricken areas and had no access to electricity, telephones, potable water and other basic amenities.

[54] In October 2017, Global Communities partnered with the Foundation to start up the Youth Inclusive Entrepreneurial Development Initiative for Employment (YIEDIE) project.

The project operates in Ghana's five largest cities: Accra, Kumasi, Sekondi-Takoradi, Ashaiman, and Tema and will provide opportunities for at least 23,700 youth, between ages 17–24, who earn less than $2 per day.

This was done by a collaboration between Otumfuo-Agroecom Mobile Library Project (OAMLP), which is a subsidiary of the Otumfuo Charity Foundation, and Agroecom Ghana Ltd, a cocoa buying company.

This initiative is in line with its aim to bridge the gap in learning conditions between the urban and less privileged communities and instill reading and the use of ICT in pupils at the basic level.

This was geared towards making the literary programmes of the Young Educators Foundation available to less privileged communities and public schools in the Ashanti Region.

The Foundation was supported by the mine with an amount of 150,000 Ghana Cedis (GH₵) for the purchase and distribution of 10,000 copies of Readers and Workbooks to Junior High School Students in the catchment area.