Oude IJsselstreek (Dutch pronunciation: [ˌʌudə ˈʔɛisəlstreːk] ⓘ) is a municipality in the province of Gelderland, in the eastern Netherlands.

The municipality belongs to the transition area between the rivers in the south, coming from Germany (Rhine and Issel), and the sandy soils of the Eastern Netherlands.

Formerly from Gendringen Formerly from Wisch Terborg is the only population centre with city rights, but the largest one is Ulft with 10,000 inhabitants.

The centres along the river Oude IJssel (Ulft, Gendringen, Etten on the left border, Silvolde and Terborg on the right) constitute the urban belt, Varsseveld in the east of the municipality is a rural village and the other centres are the external territories.

Oude IJsselstreek is a member of the Ring of the European Cities of Iron Works and hosted the annual convention of 2010.